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We're set for yet another College Basketball betting prediction and pick as we head back to the ACC for this next conference clash. The Virginia Cavaliers (5-3) will officially welcome the SMU Mustangs (7-2) to their new conference as both teams open ACC play. It's time to continue our College Basketball odds series with a Virginia-SMU prediction and pick.

Virginia Basketball holds a winning record despite losing their most recent game 87-69 to No. 13 Florida. The loss broke a two-game winning streak for the Cavaliers and all of their three losses this season have come against ranked opponents (Tennessee, St. John's, Florida). They'll hope for another win as the sizable betting underdogs.

SMU Basketball will open their first ACC schedule as betting favorites in their new conference. They most recently took down Alabama State 101-72, marking their third consecutive win heading into this one. We'll get a chance to see what the Mustangs are made of as they head into the tougher part of their schedule.