Curb Your Enthusiasm star Hines joined her husband Robert F. Kennedy Jr. at UFC 314 in Florida yesterday (April 12), an event that Donald Trump also attended.

RFK Jr. is the current US Health Secretary, having been chosen by Trump for the role when he returned to office in January.

Trump spotted his party member at the sporting event last night and gave him a half-hearted hug and a handshake, and when his wife Hines put her hand out to greet the president, he appeared to completely ignore her in a now-viral moment.

And the apparent snub didn't go un-missed by Hines, who looked pretty put out afterwards as she shrugged and pulled a face.

The exchange was caught on camera as part of ESPN's coverage of the UFC event, and it wasn't long until people start discussing it on Twitter.

"Donald Trump snubbing Cheryl Hines is literally a real life Curb Your Enthusiasm moment," one person said.

Echoing similar sentiments, a second person wrote: "Donald Trump not giving RFK Jr’s wife Cheryl Hines a handshake at UFC 314 looks straight off an episode of Curb Your Enthusiasm."