Ruben Amorim admitted he is “really concerned” as Manchester United face a nervous wait over the fitness of Matthijs de Ligt.

The United boss made eight changes as his side were beaten 4-3 by Brentford, with the match coming in the middle of the Europa League semi-final tie against Athletic Bilbao.

De Ligt did start in defence, having made his return from injury in the first leg in Bilbao on Thursday, but he was forced off in the first-half after he lunged to close down Yoanne Wissa.

The centre-back went straight down and signalled to the bench that he needed to come off, as Brentford played on and scored their second goal through Kevin Schade.

De Ligt was immediately replaced as Harry Maguire came on, and Luke Shaw then came off at half-time as Amorim looked to avoid further injury concerns.

Asked for an update on De Ligt after the match, Amorim said: “I don't know so I'm really concerned - not about Thursday.

“We took off Luke Shaw at half-time to protect and have players for Thursday, but I'm more concerned whether it is a small or big injury and thinking about next season.”